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目的 :评价平阳霉素联合地塞米松治疗海绵状血管瘤的临床疗效。方法 :回顾性分析 12 8例海绵状血管瘤患者应用平阳霉素联合地塞米松进行治疗的临床资料。结果 :12 8例中注射次数最多 2 2次 ,最少 1次 ,PYM最大用量176 mg,最少 4mg,地塞米松最大用量 110 mg,最少 2 .5 m g。局部反应表现为注射当时瘤体略肿胀 ,以后则逐渐缩小变硬 ,皮肤、粘膜色泽变白 ,以后色泽渐变正常 ,最后一次治疗 3个月后复查时组织渐恢复正常弹性及形态 ,半年后形态和弹性及光泽恢复正常。 12 8例中除 5例失访外 ,其余病例最后一次治疗后门诊随访观察最短 7个月 ,最长 5 5个月均未见复发。治疗过程中除 3例出现皮疹 ,经对症处理后消失外 ,其余病例均未出现明显不良反应 ,临床治愈率为10 0 %。结论 :应用平阳霉素联合地塞米松治疗海绵状血管瘤 ,临床治愈率高 ,避免了手术给患者造成的痛苦 ,可完整保存组织的正常形态及功能 ,并克服了单独应用平阳霉素所产生的副作用 ,且两药在治疗上有协同作用
Objective: To evaluate the clinical efficacy of pingyangmycin combined with dexamethasone in the treatment of cavernous hemangioma. Methods: The clinical data of 128 cases of cavernous hemangioma treated with pingyangmycin combined with dexamethasone were retrospectively analyzed. Results: The number of injections in 12 8 cases was up to 22 times at least once, the maximum PYM dosage 176 mg, the minimum 4 mg, the maximum dosage of dexamethasone 110 mg, the least 2.5 m g. The local reaction manifested as a slight swelling of the tumor at the time of injection, then gradually reduced and hardened, and the color of the skin and mucous membrane turned white. Afterwards, the color change gradually became normal. After the last treatment for 3 months, the tissue gradually recovered to normal elasticity and morphology, And elasticity and luster returned to normal. Of the 12 8 cases, except for 5 cases lost to follow-up, the shortest follow-up observation of the other cases after the last treatment was the shortest 7 months and the longest recurrence was 55 months. During the course of treatment, except for 3 cases of rash, after symptomatic treatment disappeared, the remaining cases were no obvious adverse reactions, the clinical cure rate was 100%. Conclusion: The application of pingyangmycin combined with dexamethasone in the treatment of cavernous hemangioma, the clinical cure rate is high, to avoid the pain caused by surgery to the patient, can save the normal shape and function of the organization, and overcome the separate application of pingyangmycin produced Side effects, and the two drugs have a synergistic effect in the treatment