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背景:缺血性脑血管病患者常观察到血液流变学参数异常,这种变化虽然不是发生脑梗死的主要原因,但血液流变学改变仍不能忽视。目的:研究不同性别脑梗死和短暂性脑缺血发作患者的血液流变学变化,探讨血液流变学指标对疾病的治疗和预后评估的价值。设计:以患者和健康人为研究对象,非随机化同期对照研究。单位:一所大学医学物理研究所和一所大学医院的神经内科。对象:2000-01/12山东大学齐鲁医院神经内科住院的脑梗死患者91例,男64例,女27例,平均年龄(64±9)岁和短暂性脑缺血发作患者40例,男20例,女20例,平均年龄(58±11)岁。同期选择84例健康查体者为对照组,男52例,女32例,平均年龄(56±10)岁。方法:晨起空腹采肘静脉血2mL,肝素抗凝。血液黏度测定用NXE-1锥板式粘度计(中国成都仪器厂生产)。主要观察指标:不同性别脑梗死、短暂性脑缺血发作患者和对照组的全血高切黏度、全血低切黏度、血浆黏度、血细胞比容、红细胞聚集指数和纤维蛋白原含量。结果:男性脑梗死和短暂性脑缺血患者的各项血液流变学指标明显高于对照组,差异有显著性意义(P<0.05～0.01);女性脑梗死患者的血液流变学各项指标明显高于对照组,差异有显著性意义(P<0.05～0.01)。女性短暂性脑缺血发作组的全血黏度和血浆黏度,纤维蛋白原含量与对照组
BACKGROUND: In patients with ischemic cerebrovascular disease, abnormalities of hemorheology parameters are often observed. Although this change is not the main cause of cerebral infarction, hemorheological changes can not be neglected. Objective: To study the changes of hemorheology in patients with different genders of cerebral infarction and transient ischemic attack, and to explore the value of hemorheology in the treatment and prognosis of the disease. Design: Patient and healthy subjects, non-randomized, contemporary controlled study. Unit: a university medical physics institute and a university hospital neurology. PARTICIPANTS: Thirty-one patients with cerebral infarction hospitalized in Department of Neurology, Qilu Hospital of Shandong University from January to December 2000, including 64 males and 27 females, with an average age of 64 ± 9 years and 40 patients with transient ischemic attacks. Cases, 20 females, mean age (58 ± 11) years old. During the same period, 84 healthy volunteers were selected as the control group, including 52 males and 32 females, with an average age of (56 ± 10) years. Methods: morning fasting elbow venous blood 2mL, heparin anticoagulation. Blood viscosity was measured using NXE-1 cone plate viscometer (China Chengdu Instrument Factory). MAIN OUTCOME MEASURES: Whole blood high shear viscosity, low shear viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index and fibrinogen content in patients with different gender cerebral infarction and transient ischemic attack and control group. Results: The indexes of hemorheology in male patients with cerebral infarction and transient ischemic attack were significantly higher than those in control group (P <0.05 ~ 0.01). Hemorheology in female patients with cerebral infarction Indicators were significantly higher than the control group, the difference was significant (P <0.05 ~ 0.01). The whole blood viscosity and plasma viscosity, fibrinogen content in female transient ischemic attack group were significantly higher than those in control group