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最近报告证明:长期接受完全胃肠外营养(TPN)的病人,其胆囊病的发生率增加。对人类和动物的研究表明TPN期间形成的大多数胆囊结石是胆色素结石。作者以前曾在草原犬身上研究,证明TPN引起胆囊淤滞,但不改变胆固醇饱和指数或者胆盐池大小。本研究的目的旨在确定每日输注8-肽胆囊收缩素(CCK-OP)能否防止TPN引起的胆囊淤滞。作者用雄性草原犬做实验(因为它的胆脂成分和胆道解剖及生理和人相似)。17只犬用实验室标准的实验鼠饲料喂养3月,然后随机分组:对照组6只犬继续用鼠饲料喂养;另11只犬经中心静脉插管给以肠外营养10天,其中6只犬每日用CCK—OP按5ng/Kg/分的速度由静脉输注,连续10分钟。另5只犬
Recent reports show that patients with long-term total parenteral nutrition (TPN) have an increased incidence of gallbladder disease. Studies in humans and animals show that the majority of gallstone stones formed during TPN are biliary pigment stones. The authors have previously studied prairie dogs, demonstrating that TPN causes gallbladder stasis, but does not change the cholesterol saturation index or the bile size. The purpose of this study was to determine if daily infusion of 8-cholecystokinin (CCK-OP) could prevent gallbladder stasis caused by TPN. The author experiments with male prairie dogs (because of its bile fat composition and biliary anatomy and physiology and human similar). Seventeen dogs were fed with laboratory standard laboratory rats in March and then randomized into groups: six dogs in the control group continued to be fed with rat diet; the other 11 dogs were given parenteral nutrition via central venous catheter for 10 days, of which 6 Dog daily with CCK-OP at a rate of 5ng / Kg / min infusion from the vein, continuous 10 minutes. Another 5 dogs