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目的探讨氯沙坦和培哚普利对急性心肌梗死(AMI)患者左心室重构的治疗效应。方法急性心肌梗死患者96例,随机分为3组:氯沙坦组(33例),培哚普利组(33例),对照组(30例),采用超声心动图测量入院后第1天、2周、6个月左心室收缩末期容积指数(LVESVI)、左心室舒张末期容积指数(LVEDVI)、左心室舒张早期和晚期充盈速度比值(E/A)及左心室射血分数(LVEF)的变化,并进行观察分析。结果对照组与入院基础值比较,6个月内LVESVI、LVEDVI增加,具有统计学意义(P<0·05)。氯沙坦组与培哚普利组,对照组比较,LVES-VI、LVEDVI减少,具有统计学意义(P<0·05)。氯沙坦组与培哚普利组比较,LVESVI、LVEDVI值在2周、6个月时减少,有统计学意义(P<0·05)。结论氯沙坦对AMI患者抗左心室重构效应优于培哚普利,且耐受性好。
Objective To investigate the therapeutic effect of losartan and perindopril on left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods 96 patients with acute myocardial infarction were randomly divided into three groups: losartan group (33 cases), perindopril group (33 cases) and control group (30 cases). Echocardiography was used to measure the first day after admission Left ventricular end-systolic volume index (LVESVI), left ventricular end diastolic volume index (LVEDVI), early left ventricular diastolic filling velocity ratio (E / A) and left ventricular ejection fraction (LVEF) The changes and the observation and analysis. Results Compared with the baseline value of admission, LVESVI and LVEDVI increased within 6 months in the control group, with statistical significance (P <0.05). The LVES-VI and LVEDVI decreased in losartan group, perindopril group and control group, with statistical significance (P <0.05). Compared with the perindopril group, the values of LVESVI and LVEDVI in losartan group and in perindopril group decreased at 2 weeks and 6 months, with statistical significance (P <0.05). Conclusion Losartan has better anti-left ventricular remodeling effect than perindopril in patients with AMI.