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目的:分析小剂量来氟米特治疗类风湿关节炎长期疗效。方法:选取从2012年5月-2014年5月收治的40例类风湿关节炎,随机分为对照组(20)与观察组(20),对照组采用甲氨蝶呤,观察组给予小剂量来氟米特,对比两组长期疗效。结果:12个月,两组医生总体评价、肿胀关节数、压痛关节数有明显差异(P<0.05);18个月,观察组医患对疾病总体评价、肿胀关节数优于对照组(P<0.05)。观察组未发生呕吐、恶心等胃肠道反应。结论:对类风湿关节炎采用小剂量来氟米特治疗,长期疗效良好,患者耐受性好,具有临床应用价值。
OBJECTIVE: To analyze the long-term efficacy of low-dose leflunomide in the treatment of rheumatoid arthritis. Methods: Forty patients with rheumatoid arthritis who were treated from May 2012 to May 2014 were randomly divided into control group (20) and observation group (20), methotrexate was used as control group, and small dose Leflunomide, long-term efficacy compared to two groups. Results: At 12 months, there was a significant difference (P <0.05) between the two groups in the overall evaluation of the doctors, the number of the swollen joints and the number of tender joints (P <0.05). At 18 months, the overall evaluation of the patients and the swollen joints in the observation group were better than those in the control group <0.05). The observation group did not occur vomiting, nausea and other gastrointestinal reactions. Conclusion: Rheumatoid arthritis with low-dose leflunomide treatment, long-term efficacy, patient tolerance, and has clinical value.