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为研究慢性肾功能衰竭患者血脂质变化，检测40例慢性肾功能衰竭患者血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白AI和B水平。结果显示，慢性肾功能衰竭患者血清甘油三酯及载脂蛋白B较对照组明显升高（1．27±0．60mmol／L比0．79±0．23mmol／L，P＜0．01；0．89±0．18g／L比0．80±0．17g／L，P＜0．05）；高密度脂蛋白胆固醇、载脂蛋白AI和载脂蛋白AI／B比值均明显降低（分别为1．07±0．47mmol／L比1．41±0．29mmol／L；1．26±0．28g／L比1．46±0．10g／L；1．41比1．82，P均＜0．01）。以上提示，慢性肾功能衰竭患者脂质代谢紊乱主要表现为甘油三酯和载脂蛋白B浓度升高，高密度脂蛋白胆固醇和载脂蛋白AI浓度降低。
Serum triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein AI and B were measured in 40 patients with chronic renal failure in order to study the changes of blood lipid in patients with chronic renal failure. The results showed that serum triglyceride and apolipoprotein B levels in patients with chronic renal failure were significantly higher than those in the control group (1.27 ± 0.60 mmol / L vs 0.79 ± 0.23 mmol / L, P <0.01; 0.89 ± 0.18g / L, 0.80 ± 0.17g / L, P <0.05). The ratios of high density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein AI / B were significantly decreased 1.07 ± 0.47 mmol / L, 1.41 ± 0.29 mmol / L, 1.26 ± 0.28 g / L, 1.46 ± 0.10 g / L, 1.41 vs 1.82, P All <0.01). The above suggests that lipid metabolism disorders in patients with chronic renal failure mainly manifested as elevated concentrations of triglycerides and apolipoprotein B, high density lipoprotein cholesterol and apolipoprotein AI concentration decreased.