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目的：评价长疗程低剂量α－干扰素口含片治疗慢性乙型肝炎及丙型肝炎的疗效。方法：采用大样本随机双盲对照实验设计，以检验患者血清学指征为判断疗效的主要标志。结果：慢性乙型肝炎α－干扰素组血清ＨＢＶＤＮＡ阴转率、ＨＢｅＡｇ阴转率和抗－ＨＢｅ阳转率均显著高于对照组（Ｐ＜０．０５），而慢性丙型肝炎α－干扰素组血清ＨＣＶＲＮＡ阴转率亦显著高于对照组（Ｐ＜０．０５）。结论：长疗程低剂量α－干扰素口含给药治疗慢性肝炎与大剂量注射给药相比，其疗效相似，但其使用方便、价廉和副反应轻。
OBJECTIVE: To evaluate the efficacy of long-term low-dose alpha-interferon buccal tablets in the treatment of chronic hepatitis B and hepatitis C. Methods: A large double-blind randomized controlled trial was designed to test the serological markers of patients to determine the efficacy of the main markers. Results: Serum HBVDNA negative conversion rate, HBeAg negative conversion rate and anti-HBe positive conversion rate in patients with chronic hepatitis B alpha interferon were significantly higher than those in the control group (P <0.05), while chronic hepatitis C alpha Serum HCVRNA negative conversion rate was also significantly higher than the control group (P <0.05). Conclusion: Long-course low-dose interferon-alpha oral administration for treatment of chronic hepatitis has similar curative effect compared with high-dose injection, but it is easy to use, inexpensive and less side effects.