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目的 :探讨恶性肿瘤病人血清细胞角蛋白 19片段 (CYFRA2 1- 1)、恶性肿瘤特异性生长因子(TSGF)、糖链抗原 (CA5 0 )、癌胚抗原 (CEA)的含量改变在恶性肿瘤诊断中的意义。方法 :连续收集一年中各类恶性肿瘤病人共 6 89例 ,同时设立非恶性肿瘤组和健康体检组作为对照 ;采用放免或生化等方法检测血清CYFRA2 1- 1、TSGF、CA5 0、CEA的含量 ,然后分析比较。结果 :恶性肿瘤组的血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量分别为 6 6 4± 14 2 5 (ng/ml)、79 73± 15 94 (U/ml)、12 37± 30 5 8(U/ml)、14 2 0± 38 76 (ng/ml) ,均明显高于非恶性肿瘤组和健康体检组 ,差异有高度显著性 (p <0 0 1)。CYFRA2 1- 1、TSGF、CA5 0、CEA测定的敏感度分别为 35 3%、6 9 1%、8 0 %、12 0 % ,测定的特异度分别为 91 7%、83 3%、98 6 %、93 1% ;四项联检的阳性率明显提高。对于各类恶性肿瘤 ,TSGF含量均高于对照组 ,差异有高度显著性 (p <0 0 1) ,检测的阳性率一般 >6 0 % ;大部分恶性肿瘤的血清CYFRA2 1- 1水平亦升高 ,与对照组相比差异有显著性 (p <0 0 5 )。结论 :通过恶性肿瘤 6 89例分析 ,联合检测血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量能提高恶性肿瘤诊断的阳性率 ;CYFRA2 1- 1和TSGF测定在肿瘤临床诊断和?
Objective: To investigate the changes of serum cytokeratin 19 (CYFRA21-1), tumour specific growth factor (TSGF), carbohydrate antigen (CA50), and carcinoembryonic antigen (CEA) levels in malignant tumors. The meaning in. METHODS: A total of 689 consecutive patients with various types of malignant tumors were collected during the year. At the same time, non-malignant tumor groups and healthy checkup groups were set up as controls; serum CYFRA21-1, TSGF, CA50, and CEA levels were detected by radioimmunoassay or biochemical methods. The content is then analyzed and compared. Results: The serum levels of CYFRA21-1, TSGF, CA50, and CEA in the malignant tumor group were 646 ± 1425 (ng/ml), 7973 ± 1594 (U/ml), and 1237 ± 30 5, respectively. 8 (U/ml) and 14 2 0± 38 76 (ng/ml) were significantly higher than those in the non-malignant tumor group and the physical examination group, and the differences were highly significant (p < 0 01). The sensitivity of CYFRA21-1, TSGF, CA50, and CEA were 35 3%, 69%, 80%, and 120%, respectively, and the specificities were 91 7%, 83 3%, and 98 6 respectively. %, 93 1% ; The positive rate of the four joint inspections has increased significantly. For all types of malignant tumors, TSGF levels were higher than in the control group, the difference was highly significant (p <0 01), the detection rate was generally> 60%; the majority of malignant tumor serum CYFRA21-1 levels also rose High, compared with the control group, the difference was significant (p < 0 05). Conclusion : Through analysis of 6, 89 cases of malignant tumors, combined detection of serum CYFRA2-1 -1, TSGF, CA50, CEA levels can increase the positive rate of diagnosis of malignant tumors; CYFRA21-1 and TSGF determination in the clinical diagnosis of cancer and?