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内皮素在神经元、垂体和外周内分泌细胞中产生,通过广泛分布于神经内分泌系统的特异性内皮素受体(主要为ETA亚型)发挥作用,内皮索受体具有与其它Ca~(2+)启动受体相同的信号传递系统——诱导IP_3和DG的产生,提高细胞内Ca~(2+)浓度。其动力学特征与其它同类激动剂相似。本文综述以下内容:内皮素介导的细胞信号传递所产生的生理效应与若干神经内分泌及其作用的调节有关,调控对象包括神经肽的释放,垂体激素的分泌,性腺与胎盘的功能,水和电解质平衡及糖元分解等。
Endothelin is produced in neurons, pituitary and peripheral endocrine cells and functions through specific endothelin receptors (mainly ETA subtypes) widely distributed in the neuroendocrine system. Endothelin receptors have the ability to interact with other Ca ~ (2+) ) Initiates the same signaling system of the receptor - inducing the production of IP_3 and DG and increasing intracellular Ca ~ (2+) concentration. Its kinetic characteristics are similar to other similar agonists. This review summarizes the following: Endothelin-mediated physiological effects of cellular signaling are involved in the regulation of several neuroendocrine and its effects, including the release of neuropeptides, the secretion of pituitary hormones, the function of the gonads and placenta, the effects of water and Electrolyte balance and glycogen decomposition.