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目的研究白细胞VCS参数在幼儿巨细胞病毒(CMV)感染不同阶段的的变化趋势,探讨VCS各参数在病毒感染性疾病中的变化特点及临床应用意义。方法研究对象为CMV-Ig M(+)现症感染组86例,再根据尿CMV DNA结果分为CMV DNA(-)的早期感染组和(+)的感染期组,同时设既往感染[CMV-Ig G(+)]组45例,以及健康对照组58例。应用Beckman Coulter LH750全自动血细胞检测白细胞VCS参数,同时分析比较3组间白细胞VCS各参数的变化特点。结果与对照组比较,既往感染组MLV、MLS参数变化差异有统计学意义(P<0.05),其余差异无统计学意义(P>0.05)。与对照组比较,早期感染组和感染期组的白细胞VCS参数中,MNV、MLV、LVD、MMV、MVD参数增大,WBC、MLC、MLS、MMC、MMS参数逐渐变小,差异均有统计学意义(P<0.05);与早期感染组比较,感染期组参数MLC、MLS、MMS逐渐变小,而MVD逐渐变大,差异均有统计学意义(P<0.05)。结论白细胞VCS参数在幼儿CMV感染后不同时期具有不同的变化,可以为CMV感染的发病进展提供辅助诊断价值。
Objective To study the change trend of leukocyte VCS parameters in different stages of young children’s cytomegalovirus (CMV) infection and to explore the characteristics and clinical significance of the changes of VCS parameters in viral infectious diseases. Methods The subjects were infected with CMV-Ig M (+) infection and 86 cases were divided into CMV DNA (-) early infection group and (+) infection stage according to the results of urine CMV DNA. At the same time, -Ig G (+)] group of 45 cases, and healthy control group of 58 cases. The leukocyte VCS parameters were detected by Beckman Coulter LH750 automatic blood cell analyzer. Meanwhile, the changes of VCS parameters in leukocytes were analyzed and compared. Results Compared with the control group, the MLV and MLS parameters in the past infection group had significant difference (P <0.05), while the other differences were not statistically significant (P> 0.05). Compared with the control group, the parameter of MNV, MLV, LVD, MMV and MVD in WBC, MLC, MLS, MMC and MMS in early infection group and infection group were gradually decreased, the differences were statistically significant (P <0.05). Compared with the early infection group, the MLC, MLS and MMS in the infection group gradually decreased while the MVD gradually increased, the differences were statistically significant (P <0.05). Conclusions The leukocytes’ VCS parameters have different changes at different stages of childhood CMV infection, which can provide auxiliary diagnostic value for the pathogenesis of CMV infection.