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目的观察溃疡性结肠炎病人应用糖皮质激素后,血皮质醇及促肾上腺皮质激素(ACTH)水平的变化。方法研究样本为2003～2006年6月天津中医药大学第一附属医院消化科住院的28例溃疡性结肠炎患者,经醋酸泼尼松龙灌肠后监测血皮质醇及ACTH的变化并进行分析。结果经醋酸泼尼松龙灌肠后(大于45d),28例患者(共中3例患者有口服糖皮质激素史)中有18例出现血皮质醇和促肾上腺皮质激素水平不同程度的变化。结论溃疡性结肠炎病人长期大量摄入外源性糖皮质激素与肾上腺皮质功能减退存在一定的相关性。
Objective To observe the changes of blood cortisol and adrenocorticotropic hormone (ACTH) levels in patients with ulcerative colitis after glucocorticoid administration. Methods The study samples were 28 patients with ulcerative colitis hospitalized in Department of Gastroenterology, the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from June 2003 to June 2006. The changes of blood cortisol and ACTH were monitored after prednisolone acetate enema. Results After prednisone enema (> 45 d), 18 of 28 patients (3 patients had oral glucocorticoid history) had varying degrees of changes of blood cortisol and adrenocorticotropic hormone. Conclusion There is a correlation between long-term intake of exogenous glucocorticoids and adrenocortical dysfunction in patients with ulcerative colitis.