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作为人体内重要的微量元素,铁参与了包括DNA合成、神经递质生成、髓鞘合成等多种重要生命活动[1]。脑铁代谢相关蛋白及血脑屏障共同维持着脑铁平衡,然而在大脑衰老或是病理状态下,这种平衡将被打破,异常增多的自由铁会诱导产生高活性自由基,加剧氧化应激反应从而造成神经系统的破坏,该过程与阿尔茨海默病(Alzheimer’s disease,AD)的发生发展存在重要联系[2,3]。AD临床表现以记忆功能障
As an important trace element in human body, iron participates in many important life activities including DNA synthesis, neurotransmitter production and myelin synthesis [1]. Brain iron metabolism-related proteins and the blood-brain barrier together maintain brain iron balance, however, in the brain aging or pathological conditions, this balance will be broken, the abnormal increase in free iron will induce high activity of free radicals, exacerbating oxidative stress Which leads to the destruction of the nervous system. This process has an important connection with the development of Alzheimer’s disease (AD) [2,3]. AD clinical manifestations of memory dysfunction