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无环鸟苷(Acgcloguanosine Aoevg-clocir—BM—248u)简称ACG 或ACV,制剂的商品名Cocitax,化学名9—2(羟乙氧甲基)鸟瞟呤。结构式: 为白色结晶、分子量225.2,微溶于水(2.5℃溶解度1.34mg/ml)难溶于乙醇、甲醇、氯仿等有机溶剂。无环鸟苷是近年抗单疱病毒药物中的一种新药。对单疤病毒(HSV)Ⅰ型、Ⅱ型及带状疱疹病毒均有较高的抑制病毒活性的能力。组织培养空斑抑制试验证明ACG抗HSV—Ⅰ效力是IDU 的10倍,三氟
Acgcloguanosine Aoevg-clocir-BM-248u for short ACG or ACV, formulation of the trade name Cocitax, chemical name 9-2 (hydroxyethoxymethyl) guanine. Structure: white crystal, molecular weight 225.2, slightly soluble in water (2.5 ℃ solubility 1.34mg / ml) insoluble in ethanol, methanol, chloroform and other organic solvents. Acyclovir is a new anti-herpes simplex virus drug in recent years. The single-virus (HSV) type Ⅰ, type Ⅱ and herpes zoster virus have a higher ability to inhibit the virus activity. Tissue culture plaque inhibition test showed that ACG anti-HSV-Ⅰ potency is 10 times IDU, trifluoro