Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.Although the exact underlying mechanism leading to myelin destruction is unknown,the molecular mimicry theory is the most commonly acknowledged elucidation of MS pathology.Although various antigens have been associated with MS induction,this review presents studies focused on key bacterial and viral antigens that lead to the development of MS.The research specific to a molecular mimicry theory of MS via each implicated agent is weak;however,collectively the reports provide credible support for this theory.Given that homologous sequences are not required to lead to antigenic cross-reactivity,it is reasonable to conclude that certain viral and bacterial antigens with 5-10 similar amino acids in sequence can lead to self destruction of similar myelin sequences.Thus,this literature review has provided insight to further the understanding of the etiology of multiple sclerosis. Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Although the exact underlying mechanism leading to myelin destruction is unknown, the molecular mimicry theory is the most commonly acknowledged elucidation of MS pathology. Although various antigens have been associated with MS induction, this review presents studies focused on key bacterial and viral antigens that lead to the development of MS. research specific to a molecular mimicry theory of MS via each implicated agent is weak; however, collectively the reports provide credible support for this theory. Given that homologous sequences are not required to lead to antigenic cross-reactivity, it is reasonable to conclude that certain viral and bacterial antigens with 5-10 similar amino acids in sequence can lead to self destruction of similar myelin sequences.Thus, this literature review has provided insight to further the understanding of the etiology of multiple sclerosis.