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目的探讨宫内生长发育受限患儿是否存在下丘脑-垂体-肾上腺轴功能紊乱。方法收集2012-1-1至2013-6-1在北京友谊医院儿科住院的宫内生长发育受限(intrauterine growth restriction,IUGR)患儿和适于胎龄儿(appropriate for gestational age,AGA)血清,采用ELISA方法检测血清促肾上腺皮质激素(ACTH)、皮质醇、醛固酮激素水平变化。结果 IUGR48例,AGA50例,两组性别比无差异。IUGR血清ACTH、皮质醇浓度(均数±标准差)浓度均比AGA组明显升高,且差异有统计学意义(P<0.05);IUGR血清醛固酮浓度与AGA组相比,血清水平下降,但差异无统计学意义,P>0.05。结论宫内生长发育受限患儿血清ACTH、皮质醇浓度均明显高于适于胎龄儿,提示宫内生长发育受限患儿存在下丘脑-垂体-肾上腺轴的功能紊乱。
Objective To investigate the hypothalamus-pituitary-adrenal axis dysfunction in children with intrauterine growth restriction. Methods Children with intrauterine growth restriction (IUGR) and appropriate for gestational age (AGA) sera collected from pediatric in Beijing Friendship Hospital from January 2012 to January 2013 were collected. , And the changes of serum adrenocorticotropic hormone (ACTH), cortisol and aldosterone levels were detected by ELISA. Results IUGR48 cases, AGA50 cases, no difference between the two sex ratio. Serum levels of ACTH and cortisol in IUGR were significantly higher than those in AGA group (P <0.05). Serum aldosterone level in IUGR was lower than that in AGA group The difference was not statistically significant, P> 0.05. Conclusions Serum levels of ACTH and cortisol in children with intrauterine growth restriction were significantly higher than those in gestational age children, suggesting dysfunction of hypothalamic-pituitary-adrenal axis in children with intrauterine growth restriction.