Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values and the clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP/DPD values in squamous cell carcinoma (SCC) were found to be significantly higher than the levels in non-SCC. Furthermore, in a SCC subgroup, the TP/DPD levels were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate is shown to be significantly higher in patients with low TP/DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP/DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer. We have both investigated both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP / DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values ​​and The clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP / DPD values ​​in squamous cell carcinoma (SCC) were significantly greater than the levels in non-SCC. The TP / DPD values ​​were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate was shown significantly higher in patients with low TP / DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP / DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer.