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目的:建立异甾体化合物I C_(13)位伯醇选择性氧化成α醛基的方法。方法:分别采用莫发特氧化(Moffatt Oxidation)、斯文氧化(Swern Oxidation)和氯铬酸吡啶盐(PCC)进行氧化反应。结果:三种氧化方法都能较好的将C_(13)位伯醇氧化成醛基,但在收率和醛基α、β构型比例上有所不同。结论:斯文氧化是一种高效、简便的氧化方法,能选择性的将C_(13)位伯醇氧化成目标α醛基产物,可作为异甾体化合物C_(13)伯醇氧化的可靠方法。
OBJECTIVE: To establish a method for the selective oxidation of I C 13 (13) primary aldehydes to α aldehyde groups. Methods: Oxidation was performed using Moffatt Oxidation, Swern Oxidation and PCC. Results: All three oxidation methods could oxidize C 13 primary alcohol to aldehyde group, but the ratio of yield to the α, β of aldehyde group was different. Conclusion: Sven oxidation is an efficient and simple method for the oxidation of C_ (13) primary alcohols, which can selectively oxidize C_ (13) primary alcohols to target aldehyde groups and can be used as a reliable method for the oxidation of C_ (13) primary alcohols. .