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目的观察ω-3鱼油脂肪乳在严重脓毒症的治疗中,促进器官功能改善、辅助控制炎症、以及对严重脓毒症平均住院日及总体预后的影响。方法148例严重脓毒症的患者,分为试验组和对照组,对照组给予常规治疗,试验组则给予ω-3鱼油脂肪乳治疗,其他治疗措施相同。观察指标为:临床症状、APACHEⅡ评分、血浆CRP水平、血清白蛋白、血清甘油三脂、平均住院日、死亡率。结果ω-3鱼油脂肪乳治疗组在72h后APACHEⅡ评分明显低于对照组,CRP测定在第4天后明显低于对照组,而血清白蛋白在第7天测定明显高于对照组,平均住院日在试验组明显短于对照组;试验组死亡率低于对照组。结论ω-3鱼油脂肪乳应用于严重脓毒症可以促进机体功能的恢复,缩短平均住院日,降低死亡率;而未见明显副反应。
Objective To observe the effects of omega-3 fish oil emulsion in the treatment of severe sepsis, to promote the improvement of organ function, to help control inflammation, and to have an average length of stay and the overall prognosis of severe sepsis. Methods 148 cases of severe sepsis patients were divided into experimental group and control group, the control group given conventional treatment, the experimental group was given omega-3 fish oil emulsion treatment, the other treatment the same. Observed indicators: clinical symptoms, APACHE Ⅱ score, plasma CRP levels, serum albumin, serum triglycerides, the average length of stay, and mortality. Results The APACHEⅡscore of omega-3 fish oil fat emulsion group was significantly lower than that of the control group after72hours, CRP was significantly lower than that of the control group on the4th day, while serum albumin was significantly higher than the control group on the7th day, and the average hospital stay In the experimental group was significantly shorter than the control group; experimental group mortality was lower than the control group. Conclusion Omega-3 fish oil fat emulsion applied to severe sepsis can promote the recovery of body function, shorten the average length of stay and reduce mortality; but no obvious side effects.