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目的 :观察饮食和 或运动对胰岛素抵抗的预防和治疗效果。方法 :选取初诊发现空腹血糖在 110～ 14 0md dl之间的轻度空腹高血糖人群 12 9人 ,随机分为单纯饮食组、饮食运动组和对照组 3组。在初访时分别测量空腹血糖、空腹胰岛素 ,跟踪随访 1年 ,比较不同干预方法预防和治疗胰岛素抵抗的效果。结果 :干预 1年后 ,2个干预组平均胰岛素敏感性均显著提高 (P <0 0 1) ,并且饮食运动组平均胰岛素敏感性明显高于单纯饮食组 (P =0 0 11) ;2个干预组分别与对照组相比 ,平均胰岛素敏感性指数均显著升高 (P <0 0 1) ,但平均空腹血糖水平饮食运动组显著下降 (P <0 0 1) ,而单纯饮食组则无统计学意义上的改变 (P =0 4 5 4 )。 1年后 ,调整性别、年龄及BMI、血压、血脂的变化后 ,胰岛素敏感性改变与不同的干预方法显著相关 (r=0 .4 5 2 6,P =0 0 0 0 ) ,即干预措施越强化 ,胰岛素敏感性改变越明显。结论 :1 生活方式干预短期内 ( 1年 )可以明显提高胰岛素的敏感性 ;2 饮食运动干预治疗效果明显优于单纯饮食治疗 ,提示运动在短期内提高胰岛素敏感性、降低空腹血糖的重要作用 ,而饮食控制也许需要更为长期的干预才能达到预期效果
Objective: To observe the effect of diet and exercise on the prevention and treatment of insulin resistance. Methods: A total of 129 individuals with mild fasting hyperglycemia, whose fasting blood glucose was between 110 and 140 md dl, were randomly divided into three groups: simple diet group, exercise diet group and control group. Fasting blood glucose and fasting insulin were measured at the first visit, followed up for 1 year, and compared with different interventions to prevent and treat insulin resistance. RESULTS: After one year of intervention, the average insulin sensitivity was significantly increased in the two intervention groups (P <0.01), and the average insulin sensitivity in the exercise group was significantly higher than that in the simple diet group (P = 0.01). Two Compared with the control group, the mean insulin sensitivity index (P <0.01) in the intervention group was significantly increased (P <0.01), while the average fasting glucose level in the exercise group decreased significantly (P <0.01), while in the simple diet group Statistical changes (P = 0 4 5 4). One year later, changes in gender, age and BMI, blood pressure, and blood lipids were significantly associated with different interventions (r = .4 5 2 6, P = 0 0 0 0) as a result of interventions The more intensive, the more obvious changes in insulin sensitivity. Conclusion: 1 lifestyle intervention in a short period (1 year) can significantly improve insulin sensitivity; 2 diet exercise intervention was significantly better than simple diet therapy, suggesting that exercise in the short term to improve insulin sensitivity and reduce the important role of fasting blood glucose, Dietary control may require longer-term interventions to achieve the desired results