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详细研究了无溶剂条件下L-脯氨酸甲酯催化环戊酮与一系列醛间的直接羟醛缩合反应,结果表明:对于环戊酮与醛的羟醛缩合反应,脯氨酸甲酯是一种高效的催化剂,在优化条件下,反应能给出非常好的收率和syn非对映选择性(可达100%).
L-proline methyl ester catalyzed direct aldol condensation between cyclopentanone and a series of aldehydes under solvent-free conditions was studied in detail. The results showed that for the aldol reaction between cyclopentanone and aldehydes, proline methyl ester Is an efficient catalyst that gives very good yields and syn diastereoselectivity (up to 100%) under optimized conditions.