目前,微管蛋白结合剂应为临床应用最为有效的一类抗癌药物,一般是通过对微管的解聚或稳定作用而发挥其抗癌功效。微管是细胞的重要成分,构成有丝分裂器,关系到细胞运动、附着和胞内转运。长春碱类药物,尤其是长春新碱和长春碱已在临床上应用多年,近来又发现长春瑞宾可用于治疗 At present, the tubulin binding agent should be the most effective type of anticancer drug for clinical application, and generally exerts its anticancer efficacy by depolymerization or stabilization of microtubules. Microtubules are important cellular components that make up the mitotic device and are involved in cellular movement, attachment and intracellular transport. Vinca alkaloids, especially vincristine and vinblastine, have been used clinically for many years and recently vinorelbine has also been found to be useful in the treatment of