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目的了解本院解脲脲原体(ureaplasma urealyticum,UU)的感染现状和耐药性变迁,为临床合理用药提供依据。方法 2013—2015年收集本院门诊送检的UU检测样本4 638例,调查不同年龄、性别泌尿生殖道UU的感染情况。计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果三年来本院门诊泌尿生殖道UU检测分别为2013年1 321例,2014年1 534例,2015年1 783例,女性感染率分别为38.46%、38.61%、40.14%,均高于男性(分别为19.69%、21.55%、21.54%),差异均有统计学意义(均P<0.05);低于25岁年龄组感染阳性率分别为17.72%、23.04%和28.10%,呈上升趋势,差异有统计学意义(P<0.05)。交沙霉素耐药率分别为2.19%、0.92%和0.19%,呈下降趋势,差异有统计学意义(P<0.05);环丙沙星耐药率分别为71.78%,77.88%和84.17%,明显上升,差异有统计学意义(P<0.05)。结论女性UU的感染率明显高于男性;感染已经趋于低龄化。部分药物耐药率逐年升高,应引起重视。
Objective To understand the infection status and drug resistance changes of ureaplasma urealyticum (UU) in our hospital and provide basis for clinical rational drug use. Methods A total of 4 638 UU samples from our clinics were collected during 2013-2015 to investigate the prevalence of UU infection in genitourinary tract of different ages and genders. Counting data using χ2 test, P <0.05 for the difference was statistically significant. Results The prevalence of urogenital tract UU in our hospital during the past three years were 1321 cases in 2013, 1 534 cases in 2014 and 1 783 cases in 2015. The female infection rates were 38.46%, 38.61% and 40.14% respectively, which were higher than those of male (19.69%, 21.55%, 21.54%, respectively), the difference was statistically significant (all P <0.05). The positive rates of infection in sub-25 age group were 17.72%, 23.04% and 28.10%, respectively, There was statistical significance (P <0.05). The drug resistance rates of josamycin were 2.19%, 0.92% and 0.19%, respectively, showing a decreasing trend with statistical significance (P <0.05). The rates of resistance to ciprofloxacin were 71.78%, 77.88% and 84.17% , Significantly increased, the difference was statistically significant (P <0.05). Conclusions The infection rate of female UU is obviously higher than that of male; the infection has tended to be younger. Some drug resistance rates increased year by year, should be taken seriously.