观察31侧全身型重症肌无力(MG)患者及年龄性别配对的正常人的白细胞介素1(IL-1)的生成及影响因素。结果发现,患者外周血单核细胞(MC)在大肠杆菌脂多糖(LPS)刺激下合成和分泌的IL-1减少;患者淋巴细胞(LC)对IL-1的反应性降低,这些异常均为患者白细胞介素2(IL-2)生成减少的原因。患者IL-1生成减少又与其MC产生较高水平的前列腺素E2(PGE2)有关,而且高水平的PGE2也是生成IL-2的直接抑制物。 To observe the generation and influential factors of interleukin-1 (IL-1) in patients with systemic myasthenia gravis (MG) on the 31 side and normal persons matched by age and gender. The results showed that IL-1 synthesis and secretion in peripheral blood mononuclear cells (MCs) of patients under stimulation by E. coli lipopolysaccharide (LPS) was reduced; the reactivity of patients’ lymphocytes (LCs) with IL-1 was decreased, all of which were Causes of decreased interleukin 2 (IL-2) production in patients. Patients with reduced production of IL-1 in turn its MC to produce a higher level of prostaglandin E2 (PGE2), and high levels of PGE2 is also a direct inhibitor of IL-2.