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为了解人胎肝细胞 (FL C)对受体免疫系统及其功能的影响 ,作者采用 BAL B/ c小鼠进行了 FL C腹腔注射实验研究。实验分为空白对照和 FL C高、中、低剂量 (1 2 5× 1 0 5 ,2 5× 1 0 5 ,5× 1 0 5 胎肝细胞 /日 )组。结果显示 :FL C可增加小鼠胸腺脏器系数、外周血 T淋巴细胞数和淋巴细胞总数、脾细胞总数、抗体生成细胞数、淋巴细胞转化百分率和刺激指数 ,以及腹腔巨噬细胞吞噬作用 ,还可以影响 NK细胞活性。上述结果提示 ,人 FL C可增强小鼠非特异性免疫、体液免疫和细胞免疫功能 ,但对小鼠脾脏脏器系数无明显影响 ,也未见引起迟发型变态反应
To understand the effect of human fetal liver cells (FL C) on the immune system and its function in recipients, we used BALB / c mice to study FL C intraperitoneally. The experiment was divided into blank control group and FL C high, medium and low doses (125 × 105, 25 × 105, 5 × 105 fetal liver cells / day) group. The results showed that: FL C could increase thymus organ coefficient, the number of T lymphocytes and lymphocytes in peripheral blood, the total number of spleen cells, the number of antibody producing cells, the percentage of lymphocyte transformation and stimulating index, as well as phagocytosis of peritoneal macrophages, NK cells can also affect the activity. The above results suggest that human FL C can enhance nonspecific immunity, humoral immunity and cellular immune function in mice, but have no significant effect on the spleen organ coefficient in mice, and no delayed type hypersensitivity