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给成年雄性大鼠每日服醋酸棉酚10 mg/kg,每周服6天。服6个月后进行病理和组织化学观察。 结果说明给醋酸棉酚大鼠各主要脏器(心、肝、脾、肺、肾、肾上腺)的形态都没有明显变化。组织化学观察说明,给棉酚大鼠的肝脏油红“O”染色、G-6-P酶、ATP酶、ALP酶、ACP酶、糖原、RNA和DNA肾脏G-6-PDH、油红“O”染色、ATP酶、ACP酶、ALP酶;肾上腺3β-甾体脱氢酶、油红“O”染色、苏丹黑染色等与对照组比较都没有明显差别。
Adult male rats were given gossypol acetate 10 mg / kg daily for 6 days. After 6 months for pathological and histochemical observation. The results showed no significant changes in the morphology of major organs (heart, liver, spleen, lung, kidney, adrenal gland) of gossypol acetate rats. Histochemical observation showed that the hepatic oil red “O” staining of gossypol rats showed that G-6-P, ATPase, ALPase, ACPase, glycogen, RNA and DNA G- There was no significant difference between “O” staining, ATPase, ACPase and ALPase; adrenal 3β-steroid dehydrogenase, oil red “O” staining and Sudan black staining compared with the control group.