目的探讨原癌基因C-ETS-1蛋白质在正常月经周期子宫内膜组织中的表达。方法采用免疫组织化学方法检测C-ETS-1蛋白质在34份子宫内膜组织中的表达。结果免疫组化结果显示C-ETS-1蛋白质在不同的月经周期子宫内膜组织中的表达有所不同,在增生早、中期及分泌早、晚期呈阴性表达,增生晚期个别(1／5)呈弱阳性表达,而在分泌中期多数(5／6)呈弱阳性表达,而且C-ETS-1蛋白质在各期淋巴组织及纤维母细胞组织中也有阳性表达。结论 C- ETS-1基因可能与孕卵着床有关,它表达于孕卵着床的窗口期。 Objective To investigate the expression of protooncogene C-ETS-1 protein in normal menstrual cycle endometrium. Methods Immunohistochemistry was used to detect the expression of C-ETS-1 protein in 34 endometrial tissues. Results The results of immunohistochemistry showed that the expression of C-ETS-1 protein was different in different menstrual cycles, and it was negative in the early, middle, early and late stages of proliferation, (5/6), while C-ETS-1 protein was positive in all stages of lymphoid tissues and fibroblasts. Conclusion The C-ETS-1 gene may be involved in the implantation of the pregnant egg. It is expressed in the window of implantation during pregnancy.