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应用Ｓ－Ｐ免疫组化方法研究Ｐ５３和ｎｍ２３表达变化与胃癌生物学行及淋巴结转移的关系。发现Ｐ５３阳性染色率为４９％，Ｐ５３过表达与肿瘤浸润深度及癌细胞增殖活性呈正相关（Ｐｅａｒｓｏｎ列联系数分别为Ｐ＝０．３２和Ｐ＝０．３５，Ｐ＜０．０５），Ｐ５３阳性肿瘤的淋巴结转移率（９３％）明显高于Ｐ５３阴性的肿瘤（６０％，Ｐ＜０．０５）。同时发现ｎｍ２３低表达与胃癌侵袭程度显著相关（Ｐｅａｒｓｏｎ列联系数Ｐ＝０．２８，Ｐ＜０．０５）。ｎｍ２３低表达者淋巴结转移率（９３％）比正常表达者高（４９％，Ｐ＜０．０５）。Ｐ５３过表达和ｎｍ２３低表达在胃癌淋巴结转移中的关系为独立的联合作用。提示Ｐ５３过表达和ｎｍ２３低表达在胃癌淋巴结转移和肿瘤浸润及增殖中起重要作用。
S-P immunohistochemistry was used to study the relationship between the expression of P53 and nm23 and the biological behavior of gastric cancer and lymph node metastasis. The positive staining rate of P53 was 49%. P53 overexpression was positively correlated with tumor invasion depth and proliferation activity of cancer cells (Pearson column contact numbers were P=0.32 and P=0.35, respectively, P<0.05). P53 The lymph node metastasis rate of positive tumors (93%) was significantly higher than that of P53 negative tumors (60%, P<0.05). At the same time, it was found that low expression of nm23 was significantly associated with invasion of gastric cancer (Pearson column contact number P=0.28, P<0.05). The lymph node metastasis rate (93%) was lower in nm23 than in normal expression (49%, P<0.05). The relationship between overexpression of P53 and low expression of nm23 in lymph node metastasis of gastric cancer is an independent combined effect. It suggests that P53 overexpression and nm23 low expression play an important role in lymph node metastasis and tumor invasion and proliferation of gastric cancer.