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目的：氯化汞（ＨｇＣｌ２）具有损害肾近曲小管上皮细胞导致以急性肾小管坏死（ＡＴＮ）为特征的肾功能不全。强烈血管收缩物质内皮素－１（ＥＴ－１）可以使肾小球毛细血管血流量及肾小球滤过率降低，使这种肾功能不全模式的病态进一步恶化。本文采用内皮素受体拮抗剂（ＴＴ
PURPOSE: Mercury chloride (HgCl2) has the potential to impair renal proximal tubule epithelial cells resulting in renal insufficiency characterized by acute tubular necrosis (ATN). Endothelin-1 (ET-1), a strongly vasoconstrictive substance, decreases glomerular capillary blood flow and glomerular filtration rate, further worsening the morbidity of this model of renal insufficiency. This article uses endothelin receptor antagonist (TT