创伤后抗生素的合理应用需要对损伤区内源性细菌和它们对各种抗生素的敏感度有所了解。对抗生素的毒性、药物动力和渗透特点的熟悉亦很重要。腰部以上皮肤和肌、骨组织伤口感染多由金黄色葡萄球菌或A组链球菌等皮肤细菌所引起,腰部以下除这些常见皮肤细菌外尚有大肠杆菌和奇异变形杆菌,这些细菌可能从胃肠道落到下肢上。因此,半合成青霉素(苯甲异噁唑青霉素、茶氧青霉素、二 The rational use of post-traumatic antibiotics requires knowledge of the endogenous bacteria in the damaged area and their susceptibility to various antibiotics. Familiarity with the characteristics of antibiotic toxicity, pharmacokinetics and penetration is also important. More than the skin and muscle over the waist, wound infection of bone tissue caused by Staphylococcus aureus or Streptococcus group A and other skin bacteria, in addition to these common skin outside the waist and Escherichia coli and Proteus bacteria, these bacteria may be from the gastrointestinal Road fell to the lower limbs. Therefore, semi-synthetic penicillin (benzoxazole penicillin, tea penicillin, two