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目的探讨口服莫沙比利分散片对胶囊内镜检查中胃肠转运时间、全小肠检查完成率及胶囊内镜诊断率的影响。方法将30例患者随机分为服药组(15例)和对照组(15例),所有患者检查前1天晚餐进流质后禁食。两组患者均在检查前5 h行肠道准备。服药组检查前15 min口服莫沙比利分散片5 mg,对照组检查前不服用任何药物。结果服药组平均胃排空时间为27±18 min,对照组为:65±25 min,两组比较差异有统计学意义(P<0.05)。完成全小肠检查者通过时间服药组平均为’240±45 min,对照组平均为290±60 min,两组比较差异无统计学意义(P﹥0.05)。全小肠检查完成率服药组为93.3%,对照组为73.3%,两组比较差异有统计学意义(P<0.05)。胶囊内镜诊断率服药组为80.0%,对照组为66.7%,两组差异有统计学意义(P<0.05)。结论胶囊内镜检查前给予口服莫沙比利可以缩短胃排空时间,可能提高全小肠检查完成率和胶囊内镜诊断率。对年老体弱、胃动力不足的受检者,胶囊内镜检查前口服莫沙比利,可以提高胶囊内镜诊断率。
Objective To investigate the influence of oral Mosapride dispersible tablets on the gastrointestinal transit time, the rate of complete small bowel examination and the diagnostic rate of capsule endoscopy in capsule endoscopy. Methods Thirty patients were randomized into medication group (n = 15) and control group (n = 15). All patients were fasted after they had entered the liquid phase on the day before examination. The two groups of patients were gut prepared 5 hours before the examination. The medication group 15 min oral Mosapride dispersible tablets 5 mg, the control group before taking any medication. Results The mean gastric emptying time was 27 ± 18 min in the medication group and 65 ± 25 min in the control group. There was significant difference between the two groups (P <0.05). The average time for complete small intestine examination was 240 ± 45 minutes in the medication group and 290 ± 60 minutes in the control group. There was no significant difference between the two groups (P> 0.05). The rate of complete small intestine examination was 93.3% in the medication group and 73.3% in the control group, with significant difference between the two groups (P <0.05). The diagnostic rate of capsule endoscopy was 80.0% in the medication group and 66.7% in the control group, with significant difference between the two groups (P <0.05). Conclusion The oral administration of mosapride before capsule endoscopy can shorten the time of gastric emptying, which may improve the rate of complete small bowel examination and endoscopic diagnosis. For frail, stomach motility of the subjects, oral capsule endoscopy Mosha Billy, can improve the diagnostic rate of capsule endoscopy.