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目的:观察甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效。方法:58例异位妊娠患者按入院前后次序分为观察组及对照组各29例。对照组予甲氨蝶呤50 mg·m-2,im bid;观察组在对照组基础上,加用米非司酮片50 mg,po bid。两组疗程均为3 d。治疗后比较两组治愈率、二次用药率及不良反应发生率。结果:观察组治愈率为93.1%,高于对照组的69.0%(P<0.05);二次用药率为10.3%,明显低于对照组的48.4%(P<0.05);两组不良反应发生差异无统计学意义(P>0.05)。结论:甲氨蝶呤联合米非司酮治疗异位妊娠效果确切,能明显降低二次用药率,值得临床推广使用。
Objective: To observe the clinical efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods: 58 cases of ectopic pregnancy were divided into observation group and control group according to the order of admission before and after treatment. The control group was given methotrexate 50 mg · m-2, im bid; the observation group was added with mifepristone 50 mg po po on the basis of the control group. The two courses of treatment were 3 d. After treatment, the cure rate, the second medication rate and the incidence of adverse reactions were compared. Results: The cure rate in the observation group was 93.1%, which was higher than that in the control group (69.0%, P <0.05). The secondary drug use rate was 10.3%, which was significantly lower than that in the control group (48.4%, P <0.05) The difference was not statistically significant (P> 0.05). Conclusion: Methotrexate combined with mifepristone treatment of ectopic pregnancy exact effect, can significantly reduce the rate of secondary drug use, worthy of clinical promotion and use.