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目的 :研究缺血性中风脑水肿时 ,颈动脉推注 2 0 %甘露醇对减轻脑水肿的机理及效果。方法 :建立兔急性不完全性脑缺血模型 ,随机分为对照组、非推注组及推注组 (颈动脉推注2 0 %甘露醇 ) ,通过测定脑含水量及观察脑组织病理变化 ,评价脑水肿程度。结果 :推注组脑组织含水量显著低于非推注组 ,其脑组织病理变化亦明显轻于非推注组。结论 :颈动脉推注甘露醇可明显减轻缺血性脑水肿。
Objective: To study the mechanism and effect of carotid artery injection of 20% mannitol on cerebral edema in ischemic stroke and brain edema. Methods: A rabbit model of acute incomplete cerebral ischemia was established and randomly divided into control group, non-bolus group and bolus group (carotid artery bolus 20% mannitol). The brain water content was measured and pathological changes of brain tissue were observed , Evaluate the degree of brain edema. Results: The brain water content of the bolus group was significantly lower than that of the non-bolus group, and the histopathological changes in the brain tissue of the bolus group were significantly lighter than those of the non-bolus group. Conclusion: Carotid artery injection of mannitol can significantly reduce ischemic brain edema.