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作者编纂了近期发表的头孢三嗪(Ceft-riaxone)抗生素的药代动力学参数资料,阐述头孢三嗪随年龄不同而改变的规律。以肝肾功能正常的患者和志愿者共120例(女性27例,男性93例)。年龄分布的幅度由出生后的1天直至92岁。在消除相半衰期(t_(0.5β)方面,1～8天龄者为18.6±6.9小时,9～30天龄者为9.7±3.9小时,1～12月龄者为7.2±3.2小时,1～6岁者为6.3±1.1小时,18～49岁者为7.3±1.6小时,50～74岁者为8.3±2.2小时,75～92岁者为14.2±2.9小时。这一半衰
The authors codified the recently published pharmacokinetic parameters of Ceft-riaxone antibiotics to explain the change of ceftriaxone with age. A total of 120 cases of patients with normal liver and kidney function and volunteers (27 females, 93 males). The distribution of the age ranged from one day after birth to 92 years. The elimination half-life (t_ (0.5β), 18.6 ± 6.9 hours for 1 to 8 days old, 9.7 ± 3.9 hours for 9 to 30 days, 7.2 ± 3.2 hours for those aged 1 to 12 months, 6.3 ± 1.1 hours for 6-year-old, 7.3 ± 1.6 hours for 18-49 years, 8.3 ± 2.2 hours for those aged 50-74 years and 14.2 ± 2.9 hours for those 75-92 years