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目的探讨血清游离脂肪酸(FFA)、同型半胱氨酸(Hcy)检测对诊断急性脑梗死(ACI)的临床意义。方法选取2010年6月至2014年7月期间我院确诊治疗的ACI患者71例作为ACI组,同期选取体检中心健康人员10例作为健康组,统计采用酶联免疫吸附法检测所有受试者血清FFA、Hcy水平,应用ROC曲线分析其对ACI的诊断价值。结果 ACI组FFA、Hcy水平明显高于健康组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,FFA对AMI诊断敏感度为79.56%,特异度为84.27%,准确度为89.04%,Hcy诊断敏感度为76.16%,特异度为79.34%,准确度为84.15%,联合诊断敏感度为83.48%,特异度为86.31%,准确度为93.73%。结论 FFA、Hcy均可作为诊断ACI的重要指标,联合检测具有更高的诊断价值。
Objective To investigate the clinical significance of detecting serum free fatty acid (FFA) and homocysteine (Hcy) in the diagnosis of acute cerebral infarction (ACI). Methods Seventy-one ACI patients diagnosed and treated in our hospital from June 2010 to July 2014 were selected as the ACI group, 10 healthy people in the physical examination center were selected as the healthy group in the same period, and the serum levels of all the patients were detected by enzyme-linked immunosorbent assay FFA, Hcy levels, the use of ROC curve analysis of its diagnostic value of ACI. Results The levels of FFA and Hcy in ACI group were significantly higher than those in healthy group (P <0.05). The ROC curve analysis showed that the sensitivity and specificity of FFA in diagnosing AMI were 79.56%, 84.27% and 89.04 %. The diagnostic sensitivity of Hcy was 76.16%, the specificity was 79.34%, the accuracy was 84.15%, the sensitivity of combined diagnosis was 83.48%, the specificity was 86.31% and the accuracy was 93.73%. Conclusions Both FFA and Hcy can be used as important indicators in the diagnosis of ACI. Combined detection has a higher diagnostic value.