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目的：研究β２激动剂舒喘灵对缺氧大鼠肺动脉高压及肺β２受体ｍＲＮＡ的作用。方法：常压缺氧４周，同时用舒喘灵灌胃（５ｍｇ·ｋｇ－１·ｄ－１），用肺动脉插管测压，用ＲＴ－ＰＣＲ术测肺β２受体ｍＲＮＡ。结果：缺氧同时给舒喘灵可减轻缺氧大鼠肺动脉高压、右心室压及右心室肥厚，同时使降低的β２受体ｍＲＮＡ回升到对照水平，动脉血氧分压不受影响，对体动脉压无明显作用。结论：舒喘灵能防止缺氧引起的肺动脉高压和肺肾上腺素能β２受体ｍＲＮＡ水平的降低。
AIM: To investigate the effect of β2 agonist Shucu Ling on pulmonary hypertension and β2 receptor mRNA in hypoxic rats. Methods: Normal pressure hypoxia for 4 weeks, at the same time with salbutamol intragastrically (5mg · kg-1 · d-1), measured by pulmonary artery catheterization, RT-PCR measurement of lung β2 receptor mRNA. Results: Hypoxia to Shucu Ling can reduce pulmonary hypertension in rats, right ventricular pressure and right ventricular hypertrophy, while reducing the level of β2 receptor mRNA rose to the control level, arterial partial pressure of oxygen is not affected, the body Arterial pressure no significant effect. CONCLUSIONS: Salbutamol prevented hypoxia-induced pulmonary hypertension and decreased expression of adrenergic β2 receptor mRNA.