有人提出硝酸盐和亚硝酸盐作为潜在的致癌物或致突变物,或是其本身的作用,或是亚硝基化后的作用.作者用硝酸钠对大小鼠骨髓细胞进行染色体畸变分析和微核诱变,评价它的致突变活性的能力.实验用动物为Jassy卫生研究所的雄性大小白鼠,大鼠10～12周龄,小鼠12～14周龄,共有90只.分成5组,一个对照组和四个实验组.每组动物又分两批,一批做急性 Nitrates and nitrites have been proposed as potential carcinogens or mutagens, either by their own role or after nitrosation. The authors used sodium nitrate to analyze chromosomal aberrations in murine bone marrow cells and micro- Nuclear mutagenesis and evaluate its mutagenic activity.The experimental animals were male and female rats of Jassy Institute of Health, rats 10 to 12 weeks old, mice 12 to 14 weeks old, a total of 90. Divided into 5 groups, A control group and four experimental groups, each group of animals was divided into two batches, a group of acute