矽肺是一种进行性的结节性、纤维性病变,有时在肺外如肝、脾等网状内皮系统所在部位也可找见类似的病变,但是肺外的其他病变则很少报告。近年来,有人注意到矽可能对肾有毒害作用,但仅是根据两个临床病例推测,难以肯定其相互关系。我们在观察大鼠实验矽肺病变时发现肾脏近曲小管显示玻璃样变性,未见国内外文献报导。 Silicosis is a progressive nodular, fibrotic lesion. Similar lesions can sometimes be found in locations outside the lung such as the reticuloendothelial system of the liver and spleen, but other lesions outside the lung are rarely reported. In recent years, it has been noticed that silicon may have a toxic effect on the kidney, but it is only based on two clinical cases suggesting that it is difficult to be sure about their relationship. We observe the experimental rat silicosis lesions found in the proximal tubules of the kidneys showed glassy degeneration, no domestic and foreign literature.