目的研究探讨肺表面活性物质(PS)治疗新生儿胎粪吸入综合症(MAS)临床效果。方法在保证常规机械通气的条件下,对50例MAS患者分为对照组和观察组各25例,对照组采用临床常规治疗,而观察组在常规治疗的基础上再加上肺表面活性物质(PS)治疗。结果从a/APO2和OI两个指标上比较结果,经过统计比较,发现对照组与观察组2组临床疗效差异有明显的差异性,差异有统计学意义(P<0.05)。结论 PS治疗MAS患者有明显的临床疗效,值得临床上大力推广。 Objective To investigate the clinical effect of pulmonary surfactant (PS) in neonatal meconium aspiration syndrome (MAS). Methods Under the condition of ensuring normal mechanical ventilation, 50 cases of MAS patients were divided into control group and observation group, 25 cases in each group. The control group was treated with routine therapy, while the observation group was treated with pulmonary surfactant ( PS) treatment. Results Comparing the results of a / APO2 and OI, we found that there are significant differences in clinical curative effect between the two groups (P <0.05). Conclusion PS treatment of patients with significant clinical efficacy of MAS, it is worth to vigorously promote the clinical.