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目的 比较黛安神与阿米替林对脑卒中后抑郁的治疗效果。方法 60例首发脑卒中后伴有抑郁的患者随机分为 2组,采用单盲法分别给予黛安神和阿米替林进行治疗,于治疗前后用汉密顿抑郁量表 (HAMD)、神经功能缺损评分标准及抗抑郁药副反应量表 (ASBS)作检测。结果 黛安神对脑卒中后抑郁的疗效明显快于阿米替林,最终结果无明显差别,副作用黛安神明显少于阿米替林;黛安神组患者神经功能缺损的恢复优于阿米替林组。结论 黛安神治疗脑卒中后抑郁较阿米替林疗效快,副作用少,更利于神经功能缺损的恢复。
Objective To compare the therapeutic effect of Diane and Amitriptyline on post-stroke depression. Methods Sixty first-episode stroke-associated depression patients were randomly divided into two groups. The patients were treated with Diazepam and Amitriptyline by single-blind method. Before and after treatment, the patients were assessed with Hamilton Depression Rating Scale (HAMD), neurological function Defect score and antidepressant side effects scale (ASBS) for testing. The results of Diabetes on the efficacy of depression after stroke was significantly faster than amitriptyline, the final result was no significant difference in the side effects of diazepam was significantly less than amitriptyline; Diane Shen group of patients with neurological deficit recovery better than amitriptyline group. Conclusion Triamcinolone is more effective than amitriptyline in treating post-stroke depression with less side effects, which is more conducive to the recovery of neurological deficits.