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目的:观察肠炎宁片联合消旋卡多曲颗粒治疗小儿病毒性肠炎的临床疗效。方法:选取89例病毒性肠炎患儿为研究对象,按照随机双盲法分为观察组44例和对照组45例。对照组给予消旋卡多曲颗粒治疗,观察组在对照组用药基础上加用肠炎宁片。观察2组治疗前后肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的变化,比较2组治疗后临床症状消失时间、临床疗效及不良反应发生率。结果:治疗后,2组TNF-α及IL-6水平均较治疗前降低(P<0.05),观察组的TNF-α及IL-6水平均低于对照组(P<0.05);观察组发热、腹泻及呕吐消失时间均短于对照组(P<0.05)。观察组总有效率95.45%,高于对照组的77.78%(P<0.05)。结论:肠炎宁片联合消旋卡多曲颗粒治疗病毒性肠炎,能有效改善患儿的症状、体征,控制炎症反应,临床疗效优于单纯使用消旋卡多曲颗粒。
Objective: To observe the clinical efficacy of “Yanyanning Tablet” and “Racecadotril” in treating children with viral enteritis. Methods: Eighty-nine children with viral enteritis were selected as study subjects and divided into observation group (44 cases) and control group (45 cases) by randomized double-blind method. The control group given racecadotril particles treatment, the observation group in the control group on the basis of medication with enteritis capsule. The changes of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the two groups before and after treatment were observed. The disappearance of clinical symptoms, clinical efficacy and incidence of adverse reactions were compared between the two groups. Results: After treatment, the levels of TNF-α and IL-6 in two groups were lower than those before treatment (P <0.05), and the levels of TNF-α and IL-6 in the two groups were lower than those in the control group Fever, diarrhea and vomiting were shorter than the control group (P <0.05). The total effective rate in observation group was 95.45%, which was higher than that in control group (77.78%, P <0.05). Conclusion: The combination of ErYanNing tablet and racecadotril granules in the treatment of viral enteritis can effectively improve the symptoms and signs of children and control the inflammatory reaction, and the clinical curative effect is better than that of racecadotril alone.