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目的:研究子宫内膜间质肉瘤磁共振扩散加权成像ADC值与恶性生物学特征的相关性。方法:选择在本院接受手术切除的34例子宫内膜间质肉瘤患者作为研究的恶性组,接受手术切除的58例子宫肌瘤患者作为对照组。术前进行磁共振扩散加权成像并测定表观扩散系数(ADC值);术后收集病灶组织并测定增殖基因及雌孕激素受体的表达量。结果:恶性组子宫内膜间质肉瘤的ADC值显著低于对照组;恶性组子宫内膜间质肉瘤病灶中CyclinD1、Rb、Sp1、Survivin、ERα、ERβ、PRA、PRB的蛋白表达量显著高于对照组,SULT1E1的蛋白表达量显著低于对照组;低ADC值亚组子宫内膜间质肉瘤病灶中CyclinD1、Rb、Sp1、Survivin、ERα、ERβ、PRA、PRB的蛋白表达量显著高于高ADC值亚组,SULT1E1的蛋白表达量显著低于高ADC值亚组。结论:磁共振扩散加权成像ADC值能够用于评估子宫内膜间质肉瘤的恶性生物学行为。
OBJECTIVE: To study the correlation between ADC value and malignant biological characteristics of MRI-diffusion-weighted imaging in endometrial stromal sarcoma. METHODS: Thirty-four patients with endometrial stromal sarcoma who underwent resection in our hospital were selected as the study malignant group and 58 patients with uterine fibroids who underwent surgical resection were selected as the control group. Preoperative MRI diffusion weighted imaging and determination of apparent diffusion coefficient (ADC value); after the lesion was collected and measured the proliferation of genes and estrogen and progesterone receptor expression. Results: The ADC value of malignant group of endometrial stromal sarcoma was significantly lower than that of control group. The protein expression of CyclinD1, Rb, Sp1, Survivin, ERα, ERβ, PRA and PRB in malignant group was significantly higher The protein expression of SULT1E1 in the control group was significantly lower than that in the control group. The protein expression of CyclinD1, Rb, Sp1, Survivin, ERα, ERβ, PRA and PRB in the subgroup of low ADC value subgroup was significantly higher than that in the control group High ADC value subgroup, SULT1E1 protein expression was significantly lower than the high ADC value subgroup. CONCLUSION: MR diffusion weighted imaging ADC value can be used to evaluate the malignant biological behavior of endometrial stromal sarcoma.