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运用敏感的B_9细胞增殖试验检测了81例多发性骨髓瘤(MM)患者血清IL-6活性,同时分析了标本的几种急性相蛋白含量,结果表明,68％MM患者血清中IL-6活性大于5μ/ml(正常对照为5μ/ml以下),几种急性相蛋白中C-反应性蛋白(CRP)在MM时升高(P<0.01),平均达正常对照组的17倍以上,MM患者补体C_4与正常对照组无差异(p>0.05),C_3、白蛋白及转铁蛋白在MM时分别比正常下降24.42％、38.83％和32.80％,且与疾病分期有关,在血清IL-6大于5μ/ml的55例中,IL-6活性与CRP、C_3、白蛋白的相关系数分别为0.46,-0.34和-0.29,IL-6与转铁蛋白浓度相关不明显。本文结果提示:CRP、C_3及白蛋白等含量的变化可作为反映MM病情的简易而敏感的指标。
Serum levels of IL-6 in 81 patients with multiple myeloma (MM) were detected by sensitive B9 cell proliferation assay. Several acute phase proteins were also assayed. The results showed that serum IL-6 activity in 68% of MM patients (P <0.01), and reached an average of 17 times higher than that of the normal control group (MM C_3, albumin and transferrin decreased by 24.42%, 38.83% and 32.80%, respectively, in MM when compared with those in normal controls, and were related to disease stage. Serum levels of IL-6 Correlation coefficients of IL-6 activity with CRP, C_3 and albumin were 0.46, -0.34 and -0.29 respectively in 55 cases of more than 5μ / ml, and the correlation between IL-6 and transferrin was not obvious. The results suggest that: changes in CRP, C_3 and albumin content can be used as a simple and sensitive indicator of MM disease.