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毒扁豆碱又名依色林,其水杨酸盐为眼科常用药物之一。水杨酸毒扁豆碱的水溶液极易氧化变色。变色后毒性增加,因而在药房中应临用新配,对工作深感不便。基于变色的各种原因,过去已有人进行过实验,如为防止氧化可加入0.1%焦亚硫酸钠、亚硫酸氢钠、硫代硫酸钠等可延长30天以上不变色;为防止重金属的作用,可加入0.1%乙二胺四乙酸二钠,可延长56天。由于水杨酸毒扁豆碱在pH3.5—4.5较安定,故亦可加入缓冲剂以延缓其变色。
Also known as physostigmine, its salicylate is one of the commonly used ophthalmic medicines. Salicylic acid physostigmine easily oxidized water solution. Toxicity increased after discoloration, so in the pharmacy should be used with the new, deeply inconvenience to work. Based on various reasons of discoloration, experiments have been carried out in the past. For example, 0.1% sodium metabisulfite, sodium bisulfite and sodium thiosulfate may be added to prevent oxidation for more than 30 days without discoloration. In order to prevent the action of heavy metals, Add 0.1% disodium edetate, extend 56 days. Since salicylic acid physostigmine is more stable at pH 3.5-4.5, it can also be added to delay the discoloration of the buffer.