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目的：研究地西泮对脑缺血再灌注损伤的保护作用。方法：用四动脉结扎法制造大鼠全脑缺血再灌注模型。动物随机分成伪手术组、再灌注组、尼莫地平２ｍｇ／ｋｇ组、地西泮２ｍｇ／ｋｇ组及４ｍｇ／ｋｇ组共５组。于缺血前、再灌注前及再灌注过程中各ｉｖ给药一次。结果：地西泮使缺血再灌注造成的脑水份含量增加，丙二醛含量增高，脑组织乳酸脱氢酶含量减少及脑钙升高向正常方向逆转（Ｐ＜０．０１），并且可以有效改善再灌期间脑电图的变化（Ｐ＜０．０５），减轻锥体细胞的坏死情况。结论：地西泮对脑缺血再灌注损伤有保护作用
Objective: To study the protective effect of diazepam on cerebral ischemia-reperfusion injury. Methods: A rat model of global cerebral ischemia-reperfusion was established by four-artery ligation. Animals were randomly divided into sham operation group, reperfusion group, nimodipine 2mg / kg group, diazepam 2mg / kg group and 4mg / kg group. Before ischemia, reperfusion and reperfusion during the iv administration. Results: Diazepam increased cerebral water content, MDA content, brain lactate dehydrogenase and brain calcium increased in the normal direction (P <0.01), and Can effectively improve the EEG changes during reperfusion (P <0.05), reduce the necrosis of pyramidal cells. Conclusion: Diazepam has a protective effect on cerebral ischemia-reperfusion injury