缺氧诱导因子-1(hypoxia-induciblefactor-1,HIF-1)是细胞在缺氧条件下产生的具有转录活性的核蛋白,它能够与靶基因结合,通过转录及转录后的调控,使机体对缺血、缺氧产生适应性反应。近年大量研究表明HIF-1与机体肿瘤的发生、发展关系密切。脑肿瘤为常见的肿瘤,多为实体性,且血 Hypoxia-inducible factor-1 (HIF-1) is a transcriptionally active nuclear protein that is produced by cells under hypoxia and binds to target genes. Through transcription and post-transcriptional regulation, Right ischemia, hypoxia produce adaptive response. In recent years, a large number of studies have shown that HIF-1 is closely related to the occurrence and development of tumor in the body. Brain tumors are common tumors, mostly solid, and blood