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目的探讨亚甲蓝作为蓝染料在乳腺癌前哨淋巴结活检中的应用价值。方法对已确诊的72例乳腺癌病人亚甲蓝皮下注射后行腋窝前哨淋巴结切除,送冰冻病理检查,再行乳腺癌改良根治术,并常规腋窝淋巴结清扫,术后病理石腊切片检查前哨淋巴结及手术切除标本。结果本组病例中68例共检出前哨淋巴结132枚,失败4例。前哨淋巴结的检出率94.4%,准确率91.8%,敏感度92%,假阴性率8%,假阳性率为0。结论采用亚甲蓝作为蓝染料应用于乳腺癌前哨淋巴结活检术,其前哨淋巴结活检的各项指标与其他蓝染料(专利蓝)相当,且材料广泛、费用低廉,具有临床应用前景。
Objective To investigate the value of methylene blue as a blue dye in the sentinel lymph node biopsy of breast cancer. Methods Seventy-two breast cancer patients who had been diagnosed with subcutaneous injection of methylene blue were sent for axillary sentinel lymph node resection, frozen pathological examination was performed, modified radical mastectomy for breast cancer was performed, and routine axillary lymph node dissection was performed. Postoperative pathological paraffin sections were used to examine sentinel lymph nodes. And surgical specimens. Results In this group of cases, there were 132 SLNs detected in 68 cases and 4 failures. The detection rate of sentinel lymph node was 94.4%, the accuracy rate was 91.8%, the sensitivity was 92%, the false negative rate was 8%, and the false positive rate was 0. Conclusion Methylene blue is used as a blue dye for the sentinel lymph node biopsy of breast cancer. The indicators of sentinel lymph node biopsy are the same as other blue dyes (patent blue), and the materials are extensive and cost-effective, and have clinical application prospects.