酮康唑(Ketoconazole),商品名里素劳(Nizoral、Niso-ral、R—41400)。1978年国外首次应用于临床,治疗真菌感染、柯兴氏综合征、前列腺癌等。近几年应用已日益增多,但关于其不良反应的报道较少,本文综述如下。1 肾上腺皮质功能减退White 等首先报告酮康唑1200mg/d 有抑制肾上腺皮质激素分泌的作用。Angeli 等报告用酮康唑800mg/d 治疗5例柯兴氏综 Ketoconazole, trade name Nizoral, Niso-ral, R-41400. In 1978 for the first time abroad for clinical use, treatment of fungal infections, Cushing’s syndrome, prostate cancer. In recent years, the application has been increasing, but there are few reports on its adverse reactions. This article is summarized as follows. 1 adrenocortical hypofunction White et al first reported that ketoconazole 1200mg / d inhibited the secretion of corticotropin. Angeli et al report using ketoconazole 800mg / d treatment of 5 patients with Cushing’s syndrome