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目的探讨抗抑郁药改善慢性胃炎消化功能不良的作用机制。方法制备慢性胃炎大鼠模型,按体重随机分为对照组、模型组、米氮平组及维酶素组,米氮平组及维酶组分别以15 mg·kg-1和0.25 g·kg-1给药6周,用放射免疫法测定胃泌素的含量,计算各组胃内残余率、小肠推进比,光镜下观察胃黏膜的损伤程度。结果模型组,胃内残余率、胃泌素、胃黏膜损伤例数均明显高于对照组(P<0.01),小肠推进比明显低于对照组(P<0.01)。米氮平组和维酶素组的胃内残余率、胃泌素均明显低于模型组(P<0.05),小肠推进比均明显高于模型组(P<0.05);米氮平组的胃泌素、胃黏膜损伤例数明显低于维酶素组(P<0.05),小肠推进比明显高于维酶素组(P<0.05)。结论米氮平在改善慢性胃炎大鼠胃肠动力、胃泌素及胃黏膜损伤修复方面优于维酶素。
Objective To explore the mechanism of antidepressants in improving dyspepsia of chronic gastritis. Methods Chronic gastritis rat models were randomly divided into control group, model group, mirtazapine group and verapamil group, mirtazapine group and verapamil group with 15 mg · kg -1 and 0.25 g · kg -1 -1 for 6 weeks, the content of gastrin was determined by radioimmunoassay, and the gastric residual rate, small intestine propulsion ratio were calculated, and the degree of gastric mucosal damage was observed under light microscope. Results In the model group, the gastric residual rate, gastrin and gastric mucosal injury cases were significantly higher than the control group (P <0.01), and the small intestine propulsion ratio was significantly lower than that of the control group (P <0.01). Gastric residual rate and gastrin in the mirtazapine and vetiver groups were significantly lower than those in the model group (P <0.05), and the rates of small intestine propulsion were significantly higher than those in the model group (P <0.05) Gastrin, gastric mucosal damage was significantly lower than the number of serotonergic group (P <0.05), intestinal propulsion was significantly higher than the vitamin group (P <0.05). Conclusion Mirtazapine is better than verapamil in improving gastrointestinal motility, gastrin and gastric mucosal injury in rats with chronic gastritis.