自从Powell等发现日本粗榧种子提取物有抗癌活性后,引起了人们对三尖杉生物碱的注意,开始从分离与结构测定、合成、生源合成途径、临床试验和生理作用机理等方面进行广泛的研究。现在,从三尖杉科植物已经分离出近30种生物碱,经药理和临床试验证明[1], Since Powell et al. Found that the extract of Japanese rough seed has antitumor activity, it has drawn people’s attention to the alkaloids of Cephalotaxus, beginning with the aspects of separation and structure determination, synthesis, biological synthesis, clinical trials and physiological mechanism Extensive research. Now, nearly 30 kinds of alkaloids have been isolated from Cephalinaceae plant, proved by pharmacology and clinical trials [1],