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作者研究了31例肾功能衰竭终末期的病员,其血浆醛固酮和血浆肾素的关系很明显(r=0.832,P<0.001)。这说明这些病员肾素的分泌是肾上腺醛固酮释出的主要刺激。同时观察到的血浆醛固酮、肾素活性与血清钾的明显关系(r=0.816,P<0.001)表明这些病员的血清钾也参与了醛固酮分泌的调节。在肾衰终末期及高血压未能控制的患者,因二种激素均持续增高,而在可控制的高血压患者则常见肾素活性及血浆醛固酮正常。由此结果可以推想,降血压药及血液透析治疗之所以无效,与肾素分泌持续增高有重
The authors studied 31 patients with end-stage renal failure who had a significant relationship between plasma aldosterone and plasma renin (r = 0.832, p <0.001). This shows that these patients renin secretion is the main release of aldosterone adrenal stimulation. Concurrent observations of plasma aldosterone and renin activity in relation to serum potassium (r = 0.816, p <0.001) indicate that serum potassium is also involved in aldosterone secretion regulation in these patients. In patients with end-stage renal failure and uncontrolled hypertension, both hormones continue to increase, whereas renin activity and plasma aldosterone are common in patients with controllable hypertension. The results can be assumed that antihypertensive drugs and hemodialysis treatment is ineffective, and continued to increase with renin secretion have weight